What is what happens if ozempic is not refrigerated before first use?

Ozempic (semaglutide) is a medication that requires refrigeration before first use. If it's not kept refrigerated, several things can happen, potentially affecting its efficacy and safety:

• Reduced potency: Semaglutide is a protein-based medication, and like many proteins, it's sensitive to heat. Exposure to higher temperatures above the recommended range can degrade the semaglutide molecule, reducing its effectiveness. This means the medication might not lower blood sugar as intended. The degree of degradation depends on the temperature and duration of exposure.

• Increased risk of degradation products: Heat can cause the semaglutide to break down into different compounds, some of which may be inactive or even potentially harmful. While the exact nature and impact of these degradation products aren't fully characterized, their presence is undesirable.

• Loss of sterility (unlikely but possible): While the risk is lower than the potency issues, exposure to non-refrigerated temperatures could theoretically increase the chance of microbial contamination, although the packaging should offer some protection. This is a less likely concern compared to potency loss.

In short: Using Ozempic that hasn't been refrigerated before its first use might mean it's less effective at controlling blood sugar. In severe cases, it could potentially introduce undesirable byproducts. Do not use Ozempic that has not been properly refrigerated before first use. If you're unsure about the storage of your Ozempic, consult your pharmacist or doctor before using it. They can advise you on whether it's still safe and effective.